What TransformStreams are supposed to do is check for backpressure on the controller and use promises to communicate that back to the writer:
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Again, the answer to this question varies from company to company. And again, testing is the way to find out what works best. Typically, weekends and mornings seem to be times when multiple emails are opened, but since your audience may have different habits, it's best to experiment and then use your data to decide.